Chemometrics-augmented Plasmonic Sensing

Plasmonic sensing has evolved from a fundamental optical phenomenon to a state-of-the-art analytical tool. The key advantage of plasmonic sensing lies in measuring vibrational fingerprints of target molecules attached to plasmonic substrates whilst providing excellent sensitivity down to the single-molecule level. Despite the challenges of poor reproducibility and data processing constraints, the potential of plasmonic sensors is being realised with the help of chemometrics, such as machine learning. These tools have revolutionised plasmonic sensing, enabling the fabrication of sensors with controlled localised surface plasmon resonance hotspots and the conversion of surface-enhanced Raman scattering spectral data floods into interpretable outputs. In this talk, we will demonstrate the application of chemometrics as a guide to spectral interpretation, drawing examples from physiology studies and biomedical sensing.