Spatially Offset Raman Spectroscopy (SORS) – Recent Developments

Wednesday, October 8, 2025

10:30 AM - 10:50 AM EDT

Location: Meeting Room #4&5

Presenting Author(s)

PM

Pavel Matousek

Professor
STFC
Oxford, England, United Kingdom

Non-Presenting Author(s)

SM

Sara Mosca, PhD

Research Scientist
Central Laser Facility, STFC, Rutherford Appleton Laboratory
Oxford, England, United Kingdom
MM

Megha Mehta

Exeter University
Exeter, England, United Kingdom
WS

William H. Skinner

Postdoc
Dana-Farber Cancer Institute and Harvard Medical School
Boston, Massachusetts, United States
BG

Benjamin Gardner, BSc(Hons) PhD MRSC

Research Fellow
Exeter University
Exeter, England, United Kingdom
FP

Francesca Palombo, PhD

Associate Professor in Biomedical Spectroscopy
Exeter University
Exeter, England, United Kingdom

Project Lead(s)

NS

Nick Stone, BSc (Hons), MSc (Dist.), MSc (Dist), PhD, MBA, CSci, FInstP, FIPEM, FSAS, FRSC

Professor of Biomedical Imaging and Biosensing, Deputy Pro Vice Chancellor
Exeter University
Exeter, England, United States

In fifteen words or less, explain the significance of this contribution (Novel Aspect).: Novel approach to subsurface probing of turbid media.

Abstract Text:

This presentation will provide an update on recent developments in the area of subsurface probing of diffusely scattering (turbid) samples using Spatially Offset Raman Spectroscopy (SORS). SORS is an approach in which the illumination and collection areas on sample surface are mutually displaced by spatial offset. This enables deeper sensing than possible with conventional Raman spectroscopy where the illumination and collection zones are overlapped. SORS facilitates the non-invasive interrogation of turbid samples such as biological tissues, opaque containers (paper/plastics/glass) and pharmaceutical powder formulations (tablets/capsules) at depths typically up to several mm’s to cm’s. The method yields chemical information on the inner content of materials or containers as well as it enables to characterise their physical nature (eg temperature).