W34 - Rapid Isolation and Purification of Rare Particles in Solution

Wednesday, October 8, 2025

9:45 AM - 4:00 PM EDT

Location: Exhibit Hall

Presenting Author(s)

ws

whitney schuler

Graduate Student
UofSC Department of Chemistry
columbia, South Carolina, United States

Non-Presenting Author(s)

LD

Lexi Deford

Graduate Student
Arizona State University
Tempe, Arizona, United States
Zechariah B. Kitzhaber (he/him/his)

Postdoctoral Researcher
Oak Ridge National Laboratory
Rockwood, Tennessee, United States
TR

Tammi Richardson

University of South Carolina
Columbia, South Carolina, United States
QW

Qian Wang

UofSC Department of Chemistry and Biochemistry
Columbia, South Carolina, United States

Project Lead(s)

MM

Michael L. Myrick

Primary Investigator
University of South Carolina
Columbia, South Carolina, United States

Submitter(s)

ws

whitney schuler

Graduate Student
UofSC Department of Chemistry
columbia, South Carolina, United States

In fifteen words or less, explain the significance of this contribution (Novel Aspect).: This study introduces new and faster methods for rare particulate detection.

Abstract Text: We developed a flow-through analyzer with a mechanical fluidic control system. The system allows for the repetitive isolation and optical analysis of particle in rapid flow. In this presentation, we provide proof of concept of the instrument's ability to extract a fluorescent particle from a rapidly flowing fluid and then sequentially dilute the particle to the point of isolation from its original suspension. For this demonstration, we prepared a low density sample of fluorescently dyed polystyrene microspheres in a blue-fluorescing solution. The sample was then repeatedly cycled through the system and diluted. Measures of the fluorescence of the microspheres vs the surrounding solution for each cycle of dilution are shown.